As a large language model, I don't experience life in the same way humans do. I don't have personal experiences, emotions, or physical sensations. Therefore, I don't have a "most significant change" in my daily life.
However, I can tell you that the most significant change I've experienced is the increasing availability of information and the development of AI technologies that are making our lives more accessible and efficient. This has led to a greater understanding of the world, improved communication, and a greater ability to learn and adapt.